Haraguchi, Naoki
| Affiliation | Department of Applied chemistry and Life Science |
|---|---|
| Title | Professor |
| Fields of Research | Polymer-supported Chiral Catalyst / Functional Polymer Microsphere / Environmentally Friendly Synthetic Process |
| Degree | Ph.D (Tokyo Institute of Technology) |
| Academic Societies | The Society of Polymer Science, Japan / The Chemical Society of Japan / American Chemical Society / The Society of Synthetic Organic Chemistry, Japan / Tokai Chiemical Industry Association / The Society of Rubber Science and Technology, Japan |
| haraguchi@chem Please append ".tut.ac.jp" to the end of the address above. |
|
| Laboratory website URL | http://chem.tut.ac.jp/chiral/ |
| Researcher information URL（researchmap） | Researcher information |
Research
1. Development of polymer-supported chiral organocatalysts for catalytic asymmetric reaction
Polymer-supported chiral organocatalysts have been developed for asymmetric reactions.
2. Development of novel functional polymer microsphere
Novel monodisperse functional polymer microspheres using precipitation polymerization have been developed. The polymer microspheres were applied as support polymers of polymer-immobilized chiral catalysts for asymmetric reactions.
3. Development of environmentally friendly synthetic process
Heterogeneous polymeric chiral catalysts were applied to environmentally friendly synthetic processes such as one-pot reaction and continous flow synthesis.
Theme1：Development of polymer-supported chiral organocatalysts for catalytic asymmetric reaction
Overview
Polymer-supported chiral organocatalysts have been developed for the efficient synthesis of chiral products using asymmetric reactions. The immobilization of chiral organocatalyst onto polymer facilitates the separation of the chiral product from the reaction mixture. In addition, the recovered polymeric organocatalyst can be reused several times without the loss of catalytic activity. The ionically polymer-immobilized chiral organocatalysts and the main-chain polymers of chiral organocatalysts have also been developed.
Selected publications and works
"Synthesis of Main-Chain Ionic Polymers of Chiral Imidazolidinone Organocatalysts and Their Application to Asymmetric Diels-Alder Reactions" Adv. Synth. Catal. 2018, 360, 112-123.
"Synthesis of Cinchona Alkaloid-derived Chiral Polymers by Mizoroki-Heck Polymerization and their Application to Asymmetric Catalysis" Macromolecules 2014, 47, 1922-1928.
"Design of Main-chain Polymer of Chiral Imidazolidinone for Asymmetric Organocatalysis Application" Chem. Commun.2012, 48, 4011-4013.
"Main-Chain Ionic Chiral Polymers: Synthesis of Optically Active Quaternary Ammonium Sulfonate Polymers and Their Application in Asymmetric Catalysis" J. Am. Chem. Soc. 2010, 132, 2864-2865.
Keywords
Theme2：Development of functional polymer microsphere
Overview
Polymer microspheres have been applied to paints, coatings, diagnostic drugs, cosmetics, precision machines, etc. Well-defined functional polymer microspheres by precipitation polymerization have been developed. These funcitonal polymer microspheres have been used as support polymers of polymeric chiral catalyst for asymmetric reactions.
Selected publications and works
"Synthesis of polymer microsphere-supported chiral pyrrolidine catalysts by precipitation polymerization and their application to asymmetric Michael addition reactions" J. Polym. Sci. 2021, 59, 1072-1083. (Cover picture)
"Synthesis of core-corona polymer microsphere-supported cinchonidinium salt and its application to asymmetric synthesis" Mol. Catal. 2019, 473, 5-14.
"Synthesis of well-defined hairy polymer microspheres by precipitation polymerization and surface-initiated atom transfer radical polymerization" J. Polym. Sci. Part A: Polym. Chem. 2019, 54, 621-627.
"Synthesis of Polymer Microspheres Functionalized with Chiral Ligand by Precipitation Polymerization and Their Application to Asymmetric Transfer Hydrogenation" J. Polym. Sci. Part A: Polym. Chem. 2010, 48, 3340-3349.
Keywords
Theme3：Development of environmentally friendly organic synthetic process
Overview
Environment-friendly organic synthesis process such as one-pot reactions and continuous flow reactions have been deveploped using polymer-immobilized chiral catalysts.
Selected publications and works
"Polymer-Supported Chiral Cis-Disubstituted Pyrrolidine Catalysts and Their Application to Batch and Continuous-Flow Systems" Org. Proc. Res. Dev. 2020, 24, 2228-2233.