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Special Lecture given by Taiwanese Professors

18 Mar 2011

Friday, March 18, 2011, 13:30 - 15:30

Prof. Hong-Chang Yang, National Taiwan University
Prof. Herng-Er Horng, National Taiwan Normal University

Tumor detection using high-Tc SQUID-detected NMR and MRI (Prof. Yang)
Immunomagnetic reduction assays for biomolecules (Prof. Horng)

9F at Sogo Jikken Kenkyu Building

Tumor detection using high-Tc SQUID-detected NMR and MRI
H.-C. Yang
An overview of the current status in high-Tc SQUIDs from device engineering,

to biomagnetic applications is addressed. The research includes the magnetic

resonance resonance and imaging and applications, for instance in assaying
biomolecules C-reactive protein and tumor detection in animal model studies.

Assaying biomolecules, for instance C-reactive protein, using high-Tc
NMR is proposed and demonstrated. It was found that the time-dependent Δf
of the
Fe3O4-antiCRP-CRP shows a broadening during the conjugation period. In an
measuring field B0 the magnetic moments from the Fe3O4-antiCRP-CRP generate
gradient fields which weaken the field homogeneity, and in turn broaden the
where is frequency-domain spectral linewidth. The characterization of
cancerous livers
in rats using nuclear magnetic resonance and imaging (NMR/MRI) based on
high-Tc SQUIDs
is presented. The NMR signals, Sy(t), of cancerous tissue and control tissue
measured as functions of the pre-polarization time TBp to study the
respective longitudinal
relaxation rate T1-1. The averaged T1-1 was observed to be (6.5 ± 0.5) s-1
for control
livers and (2.85 ± 0.2) s-1 for cancerous livers, which indicate that the
T1 can be used to
distinguish the cancerous tissues from control liver tissues. The signal
intensity ratio for
tap water, cancerous tissue and control tissue respectively is 1:1.15:0.56
at TBp = 1 s.
The results are close to the signal intensity ratio of 1:1.2:0.5 calculated
from the NMR
intensity at TBp = 1 s for water, cancerous tissue and control tissue,
The high-Tc SQUID-detected NMR and MRI exhibits potential applications in
tumor detection.
Research activities in magnetoencephalography are briefly addressed.

Immunomagnetic reduction assays for biomolecules
H.-R. Horng
Magnetic nano-particles (MNPs) have been widely applied to bio-magnetism,
such as
hyperthermia, drug delivery, magnetic labeling and contrast agent for
in-vivo images,
etc., but the MNP metabolism in animals is not clear to guarantee MNP's
bio-tolerance safety.
In this work, a scanning high-Tc SQUID Biosusceptometry (SSB), composed of a
SQUID unit
and a scanning coil set, was developed to detect and localize the MNP
distribution in
living organism with the advantages of easy operation and unshielded
environment. The
noninvasive method showed a good agreement with biopsy by using SSB. In
addition to
the magnetic methods, some golden standard measurements, such as Prussian
blue stain,
Inductively-Coupled Plasma (ICP), HermatoCrit Test (HCT) and the serum iron
test were
obtained together to interpret the entire process of metabolism of MNPs,
which are
considered to have substantial potential in biomedicine applications in the

For more details:
Please contact Associate Professor Hatsukade.

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