豊橋技術科学大学

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Yoshida, Sachiko

Affiliation Department of Applied chemistry and Life Science
Title Lecturer
Fields of Research Neuroscience / Developmental Bioengineering
Degree Ph.D. (University of Tokyo)
Academic Societies Society for Neuroscience / International Brain research Organization /IEEE / Japan Neuroscience Society / The Biophysical Society of Japan / Physiological Society of Japan/
E-mail syoshida@
Please append "tut.jp" to the end of the address above.
Laboratory website URL http://rodent.chem.tut.ac.jp
Researcher information URL(researchmap) Researcher information

Theme1:Research of GABA and Glutamate mediated cerebellar development and analysis of these released patterns

Overview
GABA releasing image of cerebellar cortex

Glutamate and GABA are known to play important roles as modulators in the survival and development of cerebellar neurons. We have developed an enzyme-linked real-time assay system of released glutamate, GABA and ATP.

Selected publications and works

・Morishima T., Uematsu M., Furukawa T., Yanagawa Y., Fukuda A., Yoshida S. GABA imaging in brain slices using enzyme-linked photo analysis, Neuroscience Research 67 (2010), pp. 347-353

・Wang T., Kumada T., Morishima T., Iwata S., Kaneko T., Yanagawa Y., Yoshida S., Fukuda A. Accumulation of GABAergic Neurons, Causing a Focal Ambient GABA Gradient, and Downregulation of KCC2 Are Induced During Microgyrus Formation in a Mouse Model of Polymicrogyria, Cereb Cortex. 24(4) (2014) pp. 1088-101.

Keywords

Enzyme-linked photo assay, Glutamate, GABA, ATP, Information transmission

Theme2:Acoustic observation for intact cerebellar slices

Overview
Acoustic image of cerebellar cortex

Observation for developing cerebellar cortex by acoustic impedance microscope
In cerebellar development, granule cells migrate with elongation of parallel fibers, and form neuronal circuit in molecular layer. An acoustic impedance microscopy was useful for observation of circuit structure of no treated developing cerebellums with no invasion.

Selected publications and works

・Uematsu M., Hirai Y., Karube F., Ebihara S., Kato M., Abe K., Obata K, Yoshida S., Hirabayashi M., Yanagawa Y., Kawaguchi Y. Quantitative chemical composition of cortical GABAergic neurons revealed in transgenic Venus-expressing rats, Cerebral Cortex 18 (2008), pp. 315 - 330.

・Kobayashi K., Yoshida S., Saijo Y., Hozumi N. Acoustic impedance microscopy for biological tissue characterization, Ultrasonics 54(7) (2014), pp. 1922-8.

Title of class

Developmental Neuroscience (M44630110)


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