New synthetic route to potential medicines for type 2 diabetes

15 Sep 2015

Highly enantioselective synthesis of tertiary alkyl aryl ethers

Toyohashi Tech researchers have found that the SN2 reaction of α-chloro-β-keto esters with phenols proceeded smoothly despite the fact that the reaction occurred at a tertiary carbon. This method allows the highly enantioselective synthesis of α-aryloxy-β-keto esters for the first time. The resulting compounds can be converted into some biologically active compounds, such as a GPR119 agonist, for the potential treatment of type 2 diabetes.

Full text: New synthetic route to potential medicines for type 2 diabetes
Toyohashi Tech: Press release