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Molecular modeling of novel potent agents for treating Alzheimer's disease

11 Jun 2015


Novel curcumin derivatives proposed for inhibiting the production of amyloid-beta peptides, which are the main causal agents of Alzheimer's disease.

20150611pr.jpgToyohashi Tech researchers in cooperation with the Ukraine National Academy of Sciences proposed novel agents for inhibiting the production of amyloid-beta (Aβ) peptides, which are involved in the pathogenesis of Alzheimer's disease. Using state-of-the-art molecular simulations, interactions between amyloid precursor protein (APP) and curcumin derivatives were investigated, to elucidate the specific derivative that binds strongly to APP and inhibits the pathogenic Aβ production. The results contribute to developing new medicines that suppress Aβ peptide production.


Full text: Molecular modeling of novel potent agents for treating Alzheimer's disease
Toyohashi Tech: Press release

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